Fulminant liver failure in a patient on carbamazepine and levetiracetam treatment associated with status epilepticus
Skopp, G.; Schmitt, H.Peter.; Pedal, I.
Archiv für Kriminologie 217(5-6): 161-175
2006
ISSN/ISBN: 0003-9225 PMID: 16910300 Document Number: 595721
A 22-year-old female with a history of developmental delay and seizures successfully treated with carbamazepine and levetiracetam developed fulminant hepatic failure and subsequently died. She had been admitted to the hospital following secondary generalized seizures of 35 min duration. A circulatory shock as well as intoxication was taken into consideration during the clinical course. Autopsy failed to reveal a macroscopically discernible cause of death. Significant findings on microscopic examination included acute tubular necrosis in the kidneys, pre-existing marked accumulation of neutral lipid within the hepatocytes as well as hyperacute liver damage with evidence of almost complete hepatocyte necrosis.