Absorption of myo-inositol hexakisphosphate (InsP6) through the skin in humans
Grases, F.; Isern, B.; Perelló, J.; Sanchis, P.; Prieto, R.M.; Costa-Bauzà, A.
Die Pharmazie 61(7): 652
2006
ISSN/ISBN: 0031-7144 PMID: 16889078 Document Number: 595517
In this paper, we present a pilot study of the absorption of myo-inositol hexakisphosphate, (InsP(6)) through the skin in humans. We found that, after topical treatment with a 4% InsP(6) rich gel, InsP(6) urinary excretion increased 54% compared to the control situation (participants submitted to an InsP(6)-poor diet for 15 days, n = 6), clearly demonstrating that lnsP(6) is absorbed through the skin of humans. These results demonstrate the topical application as a suitable administration route of InsP(6) in humans.