Treatment of bronchial superinfections: data related to stability of antibiotics in portable pumps
De Calbiac, P.; Lamoureux, F.; Pourrat, X.; Bretault, L.; Marchand, S.; Grassin, J.; Antier, D.
Therapie 61(2): 139-144
2006
ISSN/ISBN: 0040-5957 PMID: 16886707 Document Number: 595315
Given many data about the stability of antibiotics in portable pump (elastomer) are lacking, this study was designed to make a point about available data and to evaluate the stability of antibiotics when exposed to temperature within 35 degrees C (average temperature measured in real conditions of use). First, to collect information about the stability of antibiotics in portable pump and to confront them with the local antibiotics protocols dedicated to the treatment of bronchial superinfection in patients with cystic fibrosis; second, to evaluate the stability of piperacillin associated with tazobactam at 35 degrees C. While measured concentrations in tazobactam did not show significant variation during the study, piperacillin measurements showed a major reduction of concentration (up to 33%), both time and concentration related to. Such information must be pointed out to prescribers and patients to ensure a cold accumulator is placed in the pump carrying-bag and to limit the duration of infusion to 24 h with a single pump. This experimental program will keep on going with the stability study of both ticarcillin and cefsulodin in portable pump.