Hormone therapy and risk for venous thromboembolism in postmenopausal women
Lacut, K.; Oger, E.
La Revue du Praticien 55(4): 389-392
2005
ISSN/ISBN: 0035-2640 PMID: 15828617 Document Number: 595005
Oral estrogens are associated with a two-fold to three-fold increased risk of venous thromboembolism in postmenopausal women. Absolute excess risk is low but higher than for contraceptive pills. Biological data and observational studies suggest that transdermal estrogens are associated with a lower risk for venous thromboembolism than oral estrogens but safety has yet to be proved. Whether addition of progestin plays a significant role is undetermined so far.
Document emailed within 1 workday
Related Documents
Høibraaten, E.; Qvigstad, E.; Arnesen, H.; Larsen, S.; Wickstrøm, E.; Sandset, P.M. 2000: Increased risk of recurrent venous thromboembolism during hormone replacement therapy--results of the randomized, double-blind, placebo-controlled estrogen in venous thromboembolism trial (EVTET) Thrombosis and Haemostasis 84(6): 961-967Kessler, C.M.; Legault, C. 1995: Effect of hormone replacement therapy on the activities of factor VII and protein C in postmenopausal women women The postmenopausal estrogen/progestin intervention trial Blood 86(10 Suppl 1): 200A
Chen, F.P.; Lee, N.; Soong, Y.K.; Huang, K.E. 2001: Short- and long-term effects of hormone replacement therapy on cardiovascular risk factors in postmenopausal women Chang Gung Medical Journal 24(7): 431-439
Lowe, G.; Rumley, A.; Woodward, M.; Vessey, M. 2000: C-reactive protein, idiopathic venous thromboembolism and hormone replacement therapy Thrombosis and Haemostasis 84(4): 730-731
Odlind, V.; Milsom, I.; Persson, I.; Victor, A. 2002: Can changes in sex hormone binding globulin predict the risk of venous thromboembolism with combined oral contraceptive pills? Acta Obstetricia et Gynecologica Scandinavica 81(6): 482-490
Betancourt, M.T.; Rodger, M.A. 2007: Risk stratification for recurrent venous thromboembolism in unprovoked venous thromboembolism patients Acta Chirurgica Belgica 107(6): 636-640
Holmegard, H.N.; Nordestgaard, B.G.; Schnohr, P.; Tybjaerg-Hansen, A.; Benn, M. 2014: Endogenous sex hormones and risk of venous thromboembolism in women and men Journal of Thrombosis and Haemostasis: Jth 12(3): 297-305
Ohta, H. 2007: Hormone replacement Up-to-date. Menopause in women and hormone replacement therapy (HRT). Indications for HRT in postmenopausal women Clinical Calcium 17(9): 1315-1324
VandeKieft, G. 1996: Postmenopausal hormone therapy and cardiovascular risk Journal of Family Practice 43(5): 437-438
Eichinger, S.; Evers, J.L.H.; Glasier, A.; La Vecchia, C.; Martinelli, I.; Skouby, S.; Somigliana, E.; Baird, D.T.; Benagiano, G.; Crosignani, P.G.; Gianaroli, L.; Negri, E.; Volpe, A.; Glasier, A.; Crosignani, P.G. 2013: Venous thromboembolism in women: a specific reproductive health risk Human Reproduction Update 19(5): 471-482
Chen, F.-P. 2009: Postmenopausal hormone therapy and risk of breast cancer Chang Gung Medical Journal 32(2): 140-147
Magee, S.R.; Taylor, J.S. 2006: Hormone therapy in postmenopausal and perimenopausal women American Family Physician 74(9): 1501-1503
Feher, M.D.; Isaacs, A.J. 1996: Is hormone replacement therapy prescribed for postmenopausal diabetic women? British Journal of Clinical Practice 50(8): 431-432
Keating, N.L.; Cleary, P.D.; Rossi, A.S.; Zaslavsky, A.M.; Ayanian, J.Z. 1999: Use of hormone replacement therapy by postmenopausal women in the United States Annals of Internal Medicine 130(7): 545-553
Kuo, S-Ming.; Stout, A.; Wactawski-Wende, J.; Leppert, P.C. 2002: Ascorbic acid status in postmenopausal women with hormone replacement therapy Maturitas 41(1): 45-50
Arteaga-Gómez, A.C.; Castellanos-Barroso, G.; Colin-Valenzuela, A.; García-Vargas, J.; Márquez-Acosta, G.; Reyes-Muñoz, E. 2011: Hormone therapy effect in postmenopausal women with history of endometrial cancer Ginecologia y Obstetricia de Mexico 79(1): 11-17
Emmerich, J.; Rosendaal, F.R.; Cattaneo, M.; Margaglione, M.; De Stefano, V.; Cumming, T.; Arruda, V.; Hillarp, A.; Reny, J.L. 2001: Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism Thrombosis and Haemostasis 86(3): 809-816
Zhang, Y. 2002: Further recognize the benefit and risk of postmenopausal hormone replacement therapy on atherosclerotic cardiovascular diseases Zhonghua Fu Chan Ke Za Zhi 37(6): 321-323
Chotnopparatpattara, P.; Panyakhamlerd, K.; Taechakraichana, N.; Tantivatana, J.; Chaikittisilpa, S.; Limpaphayom, K.K. 2001: An effect of hormone replacement therapy on skin thickness in early postmenopausal women Journal of the Medical Association of Thailand 84(9): 1275-1280
Maas, A.H.E.M.; van der Graaf, Y. 2002: Postmenopausal hormone-replacement therapy discredited, except in healthy women shortly after menopause Nederlands Tijdschrift Voor Geneeskunde 146(45): 2127-2130