Localized extramedullary relapse after autologous hematopoietic stem cell transplantation in multiple myeloma
Erkus, M.; Bolaman, Z.; Meteoglu, I.; Kadikoylu, G.
Saudi Medical Journal 26(6): 989-991
2005
ISSN/ISBN: 0379-5284 PMID: 15983690 Document Number: 594770
Extramedullary plasmacytomas are rare manifestation of plasma cell malignancies. After hematopoietic stem cell transplantation (HSCT), presentation of localized plasmacytoma with extramedullary growth is very unusual. We report a case of a 56-year-old woman with Dune-Salmon stage IIIA immunoglobulin A-kappa multiple myeloma, which presented 120 days after autologous HSCT with extramedullary plasmacytoma arising from a lymph node in supraclavicular region. The patient had no pretransplant-history related with extramedullary disease. There was no increase of plasma cells in bone marrow or monoclonal protein in urine or serum. Aspiration smears of lymph node revealed a population of plasmacytoid cells at various stages of maturation. The patient was successfully treated with local radiotherapy and has remained progression-free for more than 20 months.