Top Abstract Purchase Related
Home
>
Node
>
Subnode

Antiviral activity of cepharanthine against severe acute respiratory syndrome coronavirus in vitro

Zhang, C-hai.; Wang, Y-fei.; Liu, X-jian.; Lu, J-Hai.; Qian, C-wen.; Wan, Z-yue.; Yan, X-ge.; Zheng, H-ying.; Zhang, M-ying.; Xiong, S.; Li, J-xiang.; Qi, S-yuan.

Chinese Medical Journal 118(6): 493-496

2005

ISSN/ISBN: 0366-6999
PMID: 15788131
Document Number: 594282
In an experiment conducted to determine the antiviral activity of cepharanthine (extracted and purified from Stephania cepharantha) against severe acute respiratory syndrome coronavirus (SARS-CoV) in vitro, cepharanthine was applied at 1.56, 3.13, 6.25, 12.50, 25, 50 and 100 micro g/ml. Cepharanthine at 10 micro g/ml showed potent anti-SARS-CoV activities. In vitro tests showed that cepharanthine also had high antiviral activity against herpes simplex virus type I at 1.25-6.25 micro g/ml and against Coxsackievirus B3 at 12.5-25.0 micro g/ml.

Document emailed within 1 workday
Secure & encrypted payments

Shchukina, V.N.; Loginova, S.I.; Borisevich, S.V.; Bondarev, V.P. 2011: Present state of in vitro and in vivo studies on efficacy of medical nonspecific protective agents with respect to genotype IV coronavirus causing severe acute respiratory syndrome Antibiotiki i Khimioterapiia 56(9-10): 41-46
Wang, F-sheng.; Zhou, X-zhi. 2003: Characterization of severe acute respiratory syndrome outbreak and identification of novel coronavirus Zhonghua Yi Xue Za Zhi 83(9): 705-707
Wang, Z-gang.; Li, L-juan.; Luo, Y.; Zhang, J-yan.; Wang, M-ya.; Cheng, S-yun.; Zhang, Y-jun.; Wang, X-meng.; Lu, Y-yu.; Wu, N-ping.; Mei, L-ling.; Wang, Z-xin. 2004: Molecular biological analysis of genotyping and phylogeny of severe acute respiratory syndrome associated coronavirus Chinese Medical Journal 117(1): 42-48
Lu, J.; Zhou, B.-p.; Zhou, Y.-s.; Jiang, X.-l.; Wen, L.-x.; Le, X.-h.; Li, B.; Xu, L.-m.; Li, L.-x. 2005: Molecular cloning and expression of the severe acute respiratory syndrome-associated coronavirus nucleocapsid protein and its clinical application Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 19(1): 64-67
Yasmon, A.; Ibrahim, F.; Bela, B.; Sjahrurachman, A. 2012: Potential cross-reactivity of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) nucleocapsid (N)-based IgG ELISA assay for plasma samples from HIV-1 positive intravenous drug users (IDUs) Acta Medica Indonesiana 44(3): 193-198
Loginova, S.I.; Borisevich, S.V.; Koval'chuk, A.V.; Shtabnaia, V.V.; Pashchenko, I.I.; Khamitov, R.A.; Maksimov, V.A. 2007: The in vitro antiviral activity against the causative agent of hemorrhagic fever with renal syndrome Voprosy Virusologii 52(4): 34-36
Li, T.; Qiu, Z.; Han, Y.; Wang, Z.; Fan, H.; Lu, W.; Xie, J.; Ma, X.; Wang, A. 2003: Rapid loss of both CD4+ and CD8+ T lymphocyte subsets during the acute phase of severe acute respiratory syndrome Chinese Medical Journal 116(7): 985-987
Liao, W-jiao.; Li, Y-min.; Chen, T.; He, W-qun.; Lin, Y-ping.; Li, N. 2004: Determination of serum acute phase reaction protein in patients with severe acute respiratory syndrome Zhonghua Yu Fang Yi Xue Za Zhi 38(2): 92-93
Zhang, D.-m.; Wang, G.-l.; Lu, J.-h. 2005: Severe acute respiratory syndrome: vaccine on the way Chinese Medical Journal 118(17): 1468-1476
Spivak, N.I.; Fedorova, L.V.; Krivokhatskaia, L.D. 1983: Interferonogenic activity of coronavirus in in vitro and in vivo experiments Mikrobiolohichnyi Zhurnal 45(3): 52-55
Yam, L.Y.C.; Chan, A.Y.F.; Cheung, T.M.T.; Tsui, E.L.H.; Chan, J.C.K.; Wong, V.C.W. 2005: Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome Chinese Medical Journal 118(17): 1413-1421
Wang, J.; Wang, A-Wen.; Zou, Y-Zhuang.; Cao, L-Yuan.; Huang, W-Hui.; Huang, C.; Jin, R-Hua. 2005: Psychological and physical presentations of severe acute respiratory syndrome Zhonghua Nei Ke Za Zhi 44(1): 30-33
Xiao, Z.; Li, Y.; Chen, R.; Li, S.; Zhong, S.; Zhong, N. 2003: A retrospective study of 78 patients with severe acute respiratory syndrome Chinese Medical Journal 116(6): 805-810
Franco-Paredes, C.; Kuri-Morales, P.; Alvarez-Lucas, C.; Palacios-Zavala, E.; Nava-Frías, M.; Betancourt-Cravioto, M.; Santos-Preciado, J.é I.; Tapia-Conyer, R. 2003: Severe acute respiratory syndrome: a global overview of the epidemic Salud Publica de Mexico 45(3): 211-220
Ma, M.H.M.; Chen, S-Ying.; Chiang, W-Chu.; Su, C-Ping.; Chen, W-Jone. 2005: A clinical prediction rule for the severe acute respiratory syndrome Annals of Internal Medicine 142(3): 225; Author Reply 225-6
Thomas, P.A. 2003: Severe acute respiratory syndrome (SARS) : a bolt from the blue Indian Journal of Medical Microbiology 21(3): 150-151
Nicastri, E.; Petrosillo, N.; Macrì, G.; Ippolito, G. 2003: Severe acute respiratory syndrome: the first transmissible disease of the 21st century Recenti Progressi in Medicina 94(7-8): 295-303
Hwang, C-Shin. 2006: Olfactory neuropathy in severe acute respiratory syndrome: report of A case Acta Neurologica Taiwanica 15(1): 26-28
Gommans, J. 2003: Coping with severe acute respiratory syndrome: a personal view of the good, the bad and the ugly New Zealand Medical Journal 116(1175): U465
Wan, H.; Yu, Y.-y.; Si, C.-w.; Xu, X.-y. 2004: Clinical study on patients at early stage of severe acute respiratory syndrome Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 18(1): 73-75