Multicentric reticulohistiocytosis: report of a case with systemic disease
Stock, N.; Saikali, S.; Chevrant-Breton, J.; Leroy, J-Pierre.; Le Gall, Fçois.
Annales de Pathologie 25(1): 50-53
2005
ISSN/ISBN: 0242-6498 PMID: 15981932 Document Number: 593439
Multicentric reticulohistiocytosis (RHM) is a rare non Langherhans cell histiocytosis with skin and joint involvment. Nearly all organs can be involved. Association with cancer occurs in about 25% of cases. Association with auto-immune diseases has also been recorded. Microscopic examination shows a histiocytic nodular infiltrate made of giant cells with ground-glass appearance and PAS positive cytoplasm. Immunostaining shows cell positivity for CD68 and negativity for CD1a and S100 protein. No Birbeck granules are found at ultrastructural examination.