Reduced alpha- and beta-catenin expression predicts shortened survival in local prostate cancer
Aaltomaa, S.; Kärjä, V.; Lipponen, P.; Isotalo, T.; Kankkunen, J.P.; Talja, M.; Mokka, R.
Anticancer Research 25(6c): 4707-4712
2005
ISSN/ISBN: 0250-7005 PMID: 16334164 Document Number: 593382
The aim of this study was to determine the prognostic value of alpha- and beta-catenin expressions in localprostate cancer (PC). Materials and Methods: One hundred and eighty-one PC patients treated with radical prostatectomy were followed-up for a mean of 73 years. The alpha- and beta-catenin expression were analysed by immunohistochemistry TMT (tissue microarray technique) and light microscopy. Results: Strong a-catenin expression was related to low Gleason grade (p<0.001), cancer-free seminal vesicles (p=0.04) and low preoperative PSA (p=0.02). Strong beta-catenin expression was related to low Gleason grade (p<0.001) and cancers fi-eeseininalvesiclestatus (p=0.03). Absence of nuclear P-catenin expression was related to local disease (pT1-T-2) (p=0.05). alpha-catenin (p=0.06), beta-catenin (p=0.05), Gleason grade (p=0.03) and capsular invasion (p=0.01) were related to PSA recurrence in patients who reached PSA zero postoperative. PSA recurrence-free survival (RFS) was significantly related to Gleason grade (p<0.001), capsule invasion (p=0.01), perineural growth (p=0.05) and preoperative PSA (p=0.05). In Cox's analysis, independent predictors of PSA RFS were Gleason grade (p<0.001) and capsularinvasion (p=0.006). Low expressions of a- (p=0.06)and beta-catenin (p=0.05) were related to shortened PSA PFS. Survival was related to low alpha- (p=0.011) and beta-catenin (p=0.016) expressions. Independent predictors of shortened survival were seminal vesicle invasion (p=0.016) and low a-catenin expression (p=0.049). Conclusion: Reduced alpha- or beta-catenin expressions are related to malignant phenotype in localprostate cancer and predict PSA failure as well as shortened survival.