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Stefin A--potential application in oncological laboratory diagnosis

Warwas, M.

Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 19(109): 86-89

2005

ISSN/ISBN: 1426-9686
PMID: 16194036
Document Number: 593157
This is a review of studies on stefin A, an intracellular cysteine peptidase inhibitor of cystatin superfamily. Cystatins and target cysteine peptidases, such as cathepsins B and L have been implicated in malignant progression. The biochemical characteristics of human stefin A and its functions are presented. Special attention was paid to the potential usefulness of stefin A determination in serum and tissue cytosol (ELISA test) or tissue sections (immunohistochemistry) in the oncological laboratory diagnosis.

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