Study of proliferation and apoptosis parameters of gastric epithelium cells in patients with precancerous pathologies of the stomach
Shimchuk, S.F.
Eksperimental'naia i Klinicheskaia Gastroenterologiia 4: 68-72; 113
2005
ISSN/ISBN: 1682-8658 PMID: 16255541 Document Number: 592994
Changes in proliferation and apoptosis parameters of the gastric epithelium in patients with chronic Hp-associated gastritis were studied depending on the prevalence of the inflammatory process, presence of intestinal metaplasia and atrophic changes of the stomach glandular epithelium. The obtained results demonstrated a change in the cellular updating processes of the stomach epithelium depending on the localization, prevalence of the process, and more expressed - during the development of atrophic and dystrophic changes of the stomach mucous coat. Moderate amplification of apoptosis was recorded in focal atrophic gastritis, which was shown in the increased Iapopt and reduction of IPCNA and IcyclineD1 parameters. From then on, along with the distribution of the process, proliferation enhancement, occurrences of intestinal metaplasia and neoplasia centers, oppression of apoptosis destructions of stomach epitheliocytes was marked.