Evaluation on cytotoxicity of a new nano-hydroxyapatite as root canal filling sealer
Li, P.; Xiao, L.-y.; Li, W.; Tan, H.; Liao, Y.-m.; Yuan, M.-l.
Hua Xi Kou Qiang Yi Xue Za Zhi 23(5): 427-430
2005
ISSN/ISBN: 1000-1182 PMID: 16285554 Document Number: 592970
To evaluated the cytotoxicity of a new nano-hydroxyapatite (n-HA) root canal sealer. In this study, the cytotoxicity was evaluated by the method of MTT assay in vitro, and culture medium F12 as control, three concentrations of the soaking material cultured with mouse osteoblast separately, to test the cell relative growth rate (RGR) of every group. The toxicity graduation of the n-HA root canal sealer tends to 0 with the culture time increasing. The cell survival rate of n-HA root canal sealer showed high relatively. The OD value of cell was similar for the negative control and the extracts (P > 0.05). The result indicated that n-HA root canal sealer was compatible with the testcells.