The effects of recombinant human growth hormone on mandibular bone loss with or without teeth in the ovariectomized rats
Wang, X.-x.; Zhang, J.; Zhao, Z.-Q.; Xing, D.-y.; Chen, L.
Shanghai Kou Qiang Yi Xue 14(4): 416-418
2005
ISSN/ISBN: 1006-7248 PMID: 16155710 Document Number: 592702
To investigate the effects of recombinant human growth hormone(rh-GH )on mandibular bone loss with or without teeth in the ovariectomized rats. Three-month aged ovariectomized rats were utilized as postmenopausal osteoporosis models and all the molars in left mandibles were extracted. After operations, the rats began to receive rh-GH 1 mg.kg(-1).d(-1) with subcutaneous injection for ten days. Weight of the rats ,mineral density of the mandibular bone and 3 other parameters were measured at 8th week and 12th week. The data was analyzed with F and t test. The weight of the rats increased and mandibular bone mineral density of the rats were significantly improved after rh-GH treatment, P<0.05. Rh-GH can increase the weight of the old rats and restore mandibular bone mass in mandibles with or without teeth.