Pharmacokinetic study of intraperitoneal chemotherapy with HCPT
Ye, M.; Lin, X.-x.; Pan, H.-m.; Li, N.; Lou, F.; Jin, W.; Zheng, Y.; Wu, J.-m.
Zhongguo Zhong Yao Za Zhi 30(20): 1610-1612
2005
ISSN/ISBN: 1001-5302 PMID: 16422545 Document Number: 592693
To study the pharmacokinetic of 10-Hydroxycamptothecin HCPT by intraperitoneal administration. Six dogs were given HCPT by intraperitoneal perfusion: HCPT 2 mg x kg(-1), dissolved in 300 mL NS. During the course of experiments, peritoneal fluids and blood were sampled using a standardized protocol. The concentration of HCPT in all samples was determined by high performance liquid chromatography (HPLC). The area under the curve (AUC) of peritoneal fluids was significantly highly as compared to the AUC of femoral vein and portal vein (P < 0.001). These experiments demonstrate that intraperitoneal chemotherapy has significant effect on the pharmacokinetics of IP route of HCPT administration. This method should be a more reasonable chemotherapy for the prevention of recurrence and liver metastasis of gastric cancer, colon cancer and ovary cancer after radical resection.