Paraneoplastic neurologic syndrome and autoimmune Addison disease in a patient with thymoma
Morita, H.; Hirota, T.; Mune, T.; Suwa, T.; Ishizuka, T.; Inuzuka, T.; Tanaka, K.; Ishimori, M.; Nakamura, S.; Yasuda, K.
American Journal of the Medical Sciences 329(1): 48-51
2005
ISSN/ISBN: 0002-9629 PMID: 15654180 Document Number: 592360
A 48-year-old man with autoimmune Addison disease developed the following paraneoplastic neurologic syndromes (PNNS): limbic encephalitis, opsoclonus/myoclonus, and sensorimotor and autonomic neuropathies. An anterior mediastinal mass detected on a chest computed tomographic scan was found on resection to be a noninvasive lymphocytic thymoma. The PNNS went into remission 1 year after the thymectomy. This is the first case of thymoma associated with autoimmune Addison disease and PNNS to be described in the literature.