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Neurochemical mechanisms of dorsal pallidum in antiadverse effects of anxiolytics of different models of anxiety

Talaenko, A.N.; Krivobok, G.K.; Pankrat'ev, D.V.; Goncharenko, N.V.

Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 91(7): 776-784

2005

ISSN/ISBN: 0869-8139
PMID: 16206621
Document Number: 590699
Microinjections of glutamine acid, serotonine and campiron into globus pallidus reveal antiadverse properties of ratsin in the test with avoiding "threatening situation" but not with "illuminated site" under the conditions of rats' free choice between light and dark sites. Dopamine, apomorphine, GABA, chlordiazepoxide, phenibut and indoter injected locally into this formation of basal ganglia do not affect the mechanisms of the involuntary movement, but counteract the conditions of anxiety in both models of behaviour. These results show different functional role of monoamino- and aminoacidergic systems of dorsal pallidum in operative regulation of behaviour with changing of aversive stimulus modality. Preliminary intraperitoneal injection of functional antagonists of investigated synoptotropic followed by microinjection of monoamines and amino acids into globus pallidus reveal selective involvement of neuromediator systems of dorsal pallidum into antiadverse anxiosedative and anxioselective actions.

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