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Anti-bacterial alkaloids of Saracococca saligna

Naeem, I.; Anwar, R.; Khan, T.M.

Pakistan Journal of Pharmaceutical Sciences 18(2): 3-5

2005

ISSN/ISBN: 1011-601X
PMID: 16431389
Document Number: 589590
The crude ethanolic extract of Saracococca saligna was found to be cytotoxic and antibacterial but produced no platelet aggregation induced by ADP. Antibacterial activity of two known alkaloid, pachyaximine-A and saracodine was determined. Pachyaximine-A possessed significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. Saracodme showed moderate activity against Staphylococcus pyrogenes, Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae, Shigella boydii and Klebsiella pneumoniae.

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