Randomized evaluation of fluid resuscitation with crystalloid (saline) and colloid (polymer from degraded gelatin in saline) in pediatric septic shock
Upadhyay, M.; Singhi, S.; Murlidharan, J.; Kaur, N.; Majumdar, S.
Indian Pediatrics 42(3): 223-231
2005
ISSN/ISBN: 0019-6061 PMID: 15817970 Document Number: 589576
Objective: To compare the efficacy of crystalloid (Normal saline) and colloid (polymer from degraded Gelatin in saline-Haemaccel) intravenous fluid in restoration of circulating volume in children with septic shock. Design: Prospective, randomized, open-label trial. Setting: Pediatric Emergency and Intensive Care Unit of a tertiary care referral and teaching hospital (India). Subjects and Inclusion Criteria: 60 patients, between 1 month to 12 years of age, with septic shock, without clinical evidence of organ failure at admission or underlying immunodeficiency. Patients were admitted to paediatric care or intensive care unit between 23 March 1999 and 4 April 2000. Intervention: Resuscitation with normal saline or polymer from degraded gelatin (Haemaccel) in the boluses rate of 20 ml/kg till hemodynamic stabilization or if central venous pressure (CVP) exceeded 10 mmHg (fluid requirement beyond 40 ml/kg guided by BP and CVP). Methods: Haemodynamic parameters (heart rate, capillary filling time, pulse volume, and blood pressure) were recorded before and during resuscitation, and then 2 hourly for 12 hours. Central venous pressure line was placed within first hour, soon after starting fluids. Estimation of plasma volume and body water was done at the end of first hour of fluid resuscitation. Outcome measures: Haemodynamic stabilization (heart rate, capillary refill time, systolic BP in normal range), plasma volume at the end of fluid resuscitation and incidence of organ dysfunction. Results: 31 patients were randomized to normal saline and 29 to gelatin polymer. Both the groups were similar with respect to age, gender, primary diagnosis, initial haemodynamic parameters and PRISM score. Pneumonia (n=22; 36%), gut-associated sepsis (n=13), and dengue haemorrhagic fever (n=11) were the common primary diagnosis. Initial haemodynamic stabilization was achieved in all. The mean (SD plasma volume (saline-53.4 (2.0 ml/kg)), gelatin polymer-53.2 (1.9 ml/kg)), extracellular fluid volume, total body water and interstitial fluid volume at the end of first hour of resuscitation were similar. The requirement of inotropes, incidence of organ dysfunction and case fatality rate (Saline - 29%, gelatin polymer - 31%), were similar in two groups. Conclusion: Both normal saline and gelatin polymer solution were equally effective as resuscitation fluid with respect to restoration of plasma volume and haemodynamic stability. Normal saline upto 110 ml/kg, and gelatin polymer solution upto 70 ml/kg may be required in first hour for successful fluid resuscitation of septic shock in children.