Research actuality and expectation on embryo toxicity of traditional Chinese medicine
Lin, N.; Hu, J.-p.
Zhongguo Zhong Yao Za Zhi 30(17): 1317-1320
2005
ISSN/ISBN: 1001-5302 PMID: 16323534 Document Number: 588999
To prepare cryptotanshinone (CT)-cyclodextrin inclusion compound and improve dissolution of CT. Inclusion ratio was determined by plotting the phase solubility curve of CT versus hydroxypropyl-beta-cyclodextrin (HPCD). CT-cyclodextrin inclusion compound was made by wet grinding method. Properties of the inclusion compound was investigated by in vitro dissolution test, DTA and IR spectrum. Inclusion ratio of CT versus HPCD was 1:1. Dissolution of CT-HPCD inclusion compound at 45 min was 21.6 times of material drug. Dissolution of CT was improved remarkably in CT-HPCD inclusion compound. The complexation force of the inclusion compound was hydrogen bond formed by carbonyl group of CT and hydroxyl group of HPCD.