Design, synthesis and insulin-sensitizing activity of some peroxisome proliferator-activated gamma agonists
Zhong, C-bin.; Zhu, X-jun.; Liu, Z-rong.; Gao, X-ping.; Wang, X-chao.
Yao Xue Xue Bao 40(2): 136-140
2005
ISSN/ISBN: 0513-4870 PMID: 15875669 Document Number: 588813
Aim To find new peroxisome proliferator-activated gamma agonists with high activity and low toxicity. Methods Based on JTT-501 and JTT-20993, new isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds were designed and synthesized. Their insulin-sensitizing activities were evaluated. Results Eight new compounds were obtained. The structures of synthesized compounds were characterized by NMR, MS and IR. Four compounds (1A - 4A) showed insulin-sensitizing activities. Conclusion Compounds (1A and 3A) showed excellent insulin-sensitizing activities and should be worth further investigation.