IFN-gamma in tear fluid in patients with cystic fibrosis
Mrugacz, M.łg.; Zelazowska, B.; Bakunowicz-Lazarczyk, A.; Wysocka, J.; Minarowska, A.
Klinika Oczna 107(4-6): 287-288
2005
ISSN/ISBN: 0023-2157 PMID: 16118940 Document Number: 588667
To evaluate IFN-gamma concentration in tear fluid in CF patients. Tear samples were collected from 15 CF patients at the age 10-21, and from 15 patients in control group at the age 11-20. Cytokine levels were determined by ELISA. The concentration of IFN-gamma in tear fluid in CF patients was 10.75+/-2.23 pg/ml, and 4.06+/-0.57 pg/ml in control group. The results of this study indicate that increased concentration of IFN-gamma in the tear fluid may be an important factor in the pathogenesis of dry eye in CF patients. They also open new perspectives related to therapeutic management.