Iodine uptake and the effect of radioiodine treatment--status after the addition of iodine to salt
Vej-Hansen, A.; Nygaard, B.
Ugeskrift for Laeger 167(39): 3684-3687
2005
ISSN/ISBN: 1603-6824 PMID: 16219216 Document Number: 588356
Iodine uptake and the effect of radioiodine treatment of nontoxic goiter were investigated after the introduction of iodine to salt. A retrospective study was done of 61 patients (48 women and 13 men with a median age of 56 (range 28-78)) with nontoxic goiter, examined by 24-hour radioiodine uptake. 42 of the patients were treated with radioiodine (median 600 MBq, range 200-600 MBq). The results were compared with those from a study done 10 years ago in the same area. Iodine uptake decreased significantly, from 40% (range 16-67%) in 1981-1993 to 25% (range 13-62%) in 2001-2003. 38 of the 42 patients were examined, and of these 34 (90%) had benefited from the treatment (53% of the 38 patients showed a complete effect) as estimated by the patient and the physician, based on the patient's original symptoms and the physician's clinical judgement. Four patients developed hypothyroidism, one radiation-induced thyroiditis and three Graves" disease. Iodine uptake is significantly lowered after the addition of iodine to salt. Radioiodine therapy of nontoxic goiter will continue to be effective.