Clinical application of anagrelide as a selective inhibitor of megakaryocyte system
Najda, J.; Stella-Hołowiecka, B.
Wiadomosci Lekarskie 58(11-12): 665-669
2005
ISSN/ISBN: 0043-5147 PMID: 16594479 Document Number: 588248
Anagrelid is, in our country, comparatively a new compound selectively affecting the megakaryocyte line in bone marrow leading to its reversal inhibition, simultaneously showing some exceptional, interesting pharmacological features. Essential trombocythemia, being a sole indication for the drug administration, is one of the chronic myeloproliferative disorders which exposes individuals to significantly increased risk for thrombohaemorrhagic complications. Regarding the latest literature data, the most present therapeutic modalities in this disease were presented focusing the interest on anagrelid being, in majority of cases, the drug of choice in uncontrolled megakaryocyte proliferation. The drug therapeutic value and characteristics were presented on the background of another compounds regarded as standard therapeutic options for essential thrombocythemia.