Endobiliary brush cytology during percutaneous transhepatic cholangiodrainage in patients with obstructive jaundice
Xing, G.-S.; Geng, J.-C.; Han, X.-W.; Dai, J.-H.; Wu, C.-Y.
Hepatobiliary and Pancreatic Diseases International Hbpd Int 4(1): 98-103
2005
ISSN/ISBN: 1499-3872 PMID: 15730930 Document Number: 586918
Nonsurgical pathologic diagnosis of malignant bile duct stricture with a high sensitivity and specificity is desirable for therapeutic scheme. Percutaneous transhepatic endobiliary brush cytology in detecting obstructive jaundice is evaluated. Fifty-eight consecutive patients with obstructive jaundice underwent percutaneous transhepatic cholangiodrainage (PTCD). During the process, a brush was inserted into the bile duct through the preexisted percutaneous transhepatic 8-F sheath, then exfoliated cells were collected from the bile duct stenosis and sent for cytologic diagnosis. The suspicious results were considered of negative diagnosis. All patients had relevant clinical data and follow-up results (15 months to 3 years). Statistical analysis was performed with the chi-square test and Fisher's exact test of probabilities, and a P value0.05). The results of this study indicate that cytological brushing of biliary stricture during PTCD is a useful method to establish a diagnosis of malignant biliary stenosis with a high sensitivity, but the negative predictive value is not satisfied.