Preliminary results of radiosurgery for uveal melanoma
Xiao, J-ping.; Xu, G-zhen.; Miao, Y-jun.; Wei, W-bin.; Hu, S-min.; Tang, X.; Wang, J-zhao.; Wang, G-lu.
Zhonghua Zhong Liu Za Zhi 27(4): 241-244
2005
ISSN/ISBN: 0253-3766 PMID: 15949429 Document Number: 586662
Objective To evaluate the clinical value of stereotactic radiosurgery (SRS) for uveal melanoma. Methods From Jan, 1996 to March, 2004, 16 patients with uveal melanoma were treated with SRS, two by one session (35 Gy, 25 Gy) and fourteen by fractionated SRS (30-55 Gy/2-4F/4-16D). The follow-up period ranged from 3 to 100 months (median: 66 months). Results All 16 patients were still alive though all were blind in the diseased eye during recent follow-up. Local control rate was 93.4%, 5-year survival rate of 13 patients who have been followed for more than 5 years, was 100% ( 13/13). However, 7 patients received eyeball enucleation due to corneal ulcer (n = 2), suspision for uncontrolled tumor (n = 2) and secondary glaucoma (n = 3). One patient developed distant metastasis, though still alive. Conclusion Fractionated radiosurgery is safe and effective for uveal melanoma. It is indicated for lesions of limited size(longest diameter < 20 mm, depth < 15 mm) located in the posteior pole or behind the equator at the back of the eyeball.