Imatinib mesylate STI571 therapy for five patients with advanced gastrointestinal stromal tumors
Shen, K.-t.; Hou, Y.-y.; Qin, X.-y.; Song, L.-j.; Sujie, A.
Zhonghua Wei Chang Wai Ke Za Zhi 8(2): 129-131
2005
ISSN/ISBN: 1671-0274 PMID: 16155822 Document Number: 586605
To explore the therapeutic effect of STI571(imatinib mesylate) on advanced gastrointestinal stromal tumors (GISTs). Clinical data of 5 cases with advanced GISTs were analyzed retrospectively. The expression of c- kit (CD117) was detected by immunohistochemical method in five patients with advanced GISTs . All patients failed to systematic chemotherapy or radiofrequency and operation because of extensive and multiple metastases (4 cases underwent 1 to 3 times of exploratory surgery). Tumor size was markedly decreased one to six months after STI571 given without serious drug- related side effects. STI571 is an effective chemotherapy for advanced unresectable or metastatic GISTs. Inhibitor of the Kit signal- transduction pathway is a promising regimen that is different from conventional chemotherapy for advanced GISTs.