Cognitive potential P300 in dementia with Levy's bodies and Alzheimer's disease
Koberskaia, N.N.; Zenkov, L.R.; Zakharov, V.V.; Preobrazhenskaia, I.S.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 105(1): 61-64
2005
ISSN/ISBN: 1997-7298 PMID: 15704487 Document Number: 586370
Neurodegenerative diseases accompanied by cognitive impairment (dementia with Levy's bodies - DLB and Alzheimer's disease - AD) and others) are becoming more widespread due to increasing population life expectancy. The paper addresses use of cognitive event-related potential P300 to verbal and nonverbal stimuli with an assessment of interhemispheric asymmetry and topographic distribution of P300 in patients with DLB and AD comparied to age-matched healthy controls. Specific alterations of P300 amplitude and latency suggest a use of cognitive event-related potential P300 in differential diagnosis of DLB and AD.