Effects of fluvastatin on blood levels of inflammatory cytokines in patients with unstable angina undergoing percutaneous coronary intervention
Shen, Q-shan.; Liu, Y-sheng.; Zhu, R.; Fu, D-guan.; Tang, Y-qian.; Tao, H.; Li, S-zhen.; Ye, J-wen.
Zhonghua Xin Xue Guan Bing Za Zhi 33(4): 320-322
2005
ISSN/ISBN: 0253-3758 PMID: 15932660 Document Number: 585623
Objective To investigate the effect of fluvastatin on blood levels of c-reactive protein (CRP), tumor necrosis factor alpha(TNF alpha) and cardiac troponin I (cTnI) in patients with unstable angina undergoing percutaneous coronary intervention( PCI). Methods Sixty patients who underwent PCI from July 2002 to April 2004 in our hospital were randomized into two groups: control group; fluvastatin group (40 mg/d). Serum levels of CRP, TNF alpha and cTnI were measured before and after two weeks treatment (in the early morning of the procedure) and at 24 hours after the procedure. Results The serum levels of CRP, TNF alpha and cTnI in fluvastatin group were distinctly lower than those in control group before (P < 0.01) and after the procedure(P < 0.01), respectively. Conclusion The result suggested that PCI could lead to a detectable increase in serum levels of CRP, TNF alpha and cTnI in patients with coronary heart disease; Fluvastatin could significantly decrease the serum levels of CRP, TNF alpha and cTnI in patients with coronary heart disease; Fluvastatin could also decrease the serum levels of CRP, TNF alpha and cTnI in patients with PCI.