Expression of somatostatin receptors in arginine vasopressin hormone-secreting olfactory neuroblastoma--report of two cases
Freeman, S.R.M.; Mitra, S.; Malik, T.H.; Flanagan, P.; Selby, P.
Rhinology 43(1): 61-65
2005
ISSN/ISBN: 0300-0729 PMID: 15844504 Document Number: 584923
Objective: Arginine vasopressin hormone-secreting olfactory neuroblastomas are extremely rare, with fewer than twenty cases reported in the literature. Two of these cases, both initially presenting with the syndrome of inappropriate antidiuretic hormone, are presented. The second tumour was successfully identified using somatostatin receptor (octreotide) radiographic scintogrophy.Method The pathological specimens from both cases were examined immunohistochemically for somatostatin receptors.Results: Samples from both cases demonstrated positivity for somatostatin receptors.Conclusions: This report demonstrates the potential use of somatastatin analogues in the investigation, follow-up and treatment of patients with olfactory neuroblastoma.