Tubulointerstitial nephritis with uveitis (TINU) syndrome
Szymanik-Grzelak, H.; Roszkowska-Blaim, M.; Sekowska, R.; Kamińska, A.; Weglarska, J.
Wiadomosci Lekarskie 58(Suppl 1): 98-101
2005
ISSN/ISBN: 0043-5147 PMID: 16060094 Document Number: 584612
Authors present an 11-year old girl with non-specific clinical symptoms with increase of inflammatory indices and acute non-oliguric renal failure: creatinine clearance - 55 ml/min/1.73 m2. An anterior uveitis was observed after 7 weeks of illness. Diagnosis of tubulointerstitial nephritis with uveitis (TINU) was confirmed by interstitial infiltrate (lymphocytes, neutrophils, eosinophils) and interstitial fibrosis in renal biopsy. Steroid therapy was given for 7 months. Uveitis without kidney involvement relapsed 1 month after discontinuation of steroid therapy. The full recovery of uveitis was achieved after the treatment with topical steroids. After 3 years, the illness remains still in remission.