Recent advances in proPSA on early detection in prostate cancer
Zhu, P-yuan.; Hong, P.; Huang, Y-feng.
Zhonghua Nan Ke Xue 11(12): 944-946
2005
ISSN/ISBN: 1009-3591 PMID: 16398372 Document Number: 584586
The precursor of prostate specific antigen (proPSA) are distinct molecular forms of free PSA in serum. proPSA is comprised of native proPSA as well as several truncated forms, in which [-2] proPSA and [-4] proPSA are more prostate cancer (PCa)-associated than [-7] proPSA and [-5] proPSA. Clinical studies have recently provided evidence that [-2] proPSA can significantly improve the detection of PCa, particularly in patients with total serum PSA values less than 4 microg/L. In this paper, the mechanism and characteristics of proPSA formation and impact of proPSA on the early detection of PCa are reviewed.