The PADAM syndrome and its clinical manifestations: the muscle mass
Denti, L.
Journal of Endocrinological Investigation 28(11 Suppl Proceedings): 43-45
2005
ISSN/ISBN: 0391-4097 PMID: 16760624 Document Number: 584504
Many animal and in vitro studies suggest that testosterone can affect body composition. Therefore, the age-related decline in testosterone (T) likely contributes to the concomitant decrease in lean mass documented in men. While observational data in humans are not conclusive, intervention studies suggest that aged men could benefit from T replacement in term of muscle mass preservation. However, its potential positive impact on strength and functional status is unproven.