The pathophysiology of obesity
Hernández-Jiménez, S.
Gaceta Medica de Mexico 140(Suppl 2): S27-S32
2004
ISSN/ISBN: 0016-3813 PMID: 15641469 Document Number: 584300
Obesity is a multi-cause syndrome. Overfeeding and low exercise produces excess of body fat. There are individual and population differences in energy balance, (ethnical, diet behavior, longer life expectancies). Genetic factors may influence the setting of obesity, but the calorie intake, physical activity, and lifestyle are critical determinants. As a consequence of the complex mechanisms involved in the pathogenesis of this syndrome and its complications, each model used in the diagnostic and therapeutic approach are partial. New evidences on the genetic and neuroendocrine factors in obesity are emerging, however, a holistic model is needed to understand this syndrome where biologic, psychological and social factors act together in a very intricate way. Using this model, better understanding in prevention and treatment is expected.