Hepatocyte growth factor (HGF) and atherosclerosis
Kazberuk, W.; Myśliwiec, M.ł; Galar, B.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 17(97): 88-91
2004
ISSN/ISBN: 1426-9686 PMID: 15559622 Document Number: 583778
Hepatocyte growth factor (HGF) takes part in tissue regeneration after injury. It is a potent survival and regeneration factor after severe tissue damage. It promotes cell growth and protection from apoptosis, regulates the cell migration and differentiation. HGF is a subject of intensive investigations in order to apply it in the future in gene therapy to improve treatment of angina pectoris or intermittent claudication. The aim of this review is discussion about the role of HGF in pathogenesis and treatment of atherosclerosis. Angiogenetic activity of HGF was proven in vivo as well as in vitro. In patients with collaterals increased HGF plasma concentration was revealed. It is possible to determine with high probability the risk of cardiovascular event on the basis of HGF concentration. Plasma concentration of this factor increases dramatically after heparin injection, particularly after unfractionated heparin. Also other drugs (ACE-inhibitors) may take part in regulation of HGF synthesis.