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Study on a new antarthritic injection--O-carboxymethyl chitosan

Hu, Q.; Zhang, Z.; Zhang, M.; Gao, G.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 21(1): 25-27

2004

ISSN/ISBN: 1001-5515
PMID: 15022456
Document Number: 583148
A type of water-soluble carboxymethyl chitosan (O--CMC), with 76% degree of substitution determined by conductivity method, was prepared by using chloroacetic acid to react with C6-OH of chitosan. The solubility of O--CMC was characterized also. Animal experiment in rabbits showed that O--CMC could lubricate arthron, inhibit proliferation of fibroblast cells on rabbits' knee joints, benefit the process of repairing pathologic articular cartilage, and produce good therapeutic effect on rheumatoid arthritis.

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