Homocysteine: why is it harmful?
Kagan-Ponomarev, M.I.
Angiologiia i Sosudistaia Khirurgiia 10(1): 45-50
2004
ISSN/ISBN: 1027-6661 PMID: 15163988 Document Number: 582654
This paper discusses the potential pathogenetic mechanisms by which the damaging action of hyperhomocysteinemia on the vessels is realized, namely a negative effect on the structure and function of the vessel wall, on proliferation of smooth muscle cells and endothelium-dependent vasodilatation; on the processes of blood cell interaction with the vessel wall (adhesion of monocytes, platelet adhesion and aggregation, etc): prothrombogenic action on the coagulation system, and effect of homocysteine on adenosine concentration in plasma and tissues.