How important is preventing platelet activation in the setting of percutaneous coronary intervention?
Steinhubl, S.
Journal of Invasive Cardiology 16 Suppl G: 3-7
2004
ISSN/ISBN: 1042-3931 PMID: 23570201 Document Number: 581862
The benefit of antithrombotic therapies is exerted primarily through inhibition of platelet activation and not solely through platelet aggregation. Inhibition of platelet activation can influence localized inflammatory processes as well as long-term clinical outcome. The combination of aspirin, adequate platelet inhibition with P2Y12-receptor inhibitors and thrombin inhibition can synergistically inhibit platelet activation, and the use of this combination may have important clinical implications for treatment of patients undergoing percutaneous coronary intervention.
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