Takayasu's arteritis secondary to myelodysplasia as a predictor of poor outcome: two case reports
Amberger, C.; Denzlinger, C.; Janzen, J.; Müller-Schimpfle, M.; Mohren, M.; Kötter, I.
Clinical and Experimental Rheumatology 22(3): 346-348
2004
ISSN/ISBN: 0392-856X PMID: 15144132 Document Number: 581599
We present two patients with myelodysplasia in association with Takayasu's arteritis (TA). In both patients intensive immunosuppressive treatment could not control the vascular inflammation. Subsequently both patients developed myelodysplasia, rapidly progressing to secondary acute myelogenous leukaemia. One patient had a peripheral blood stem cell transplant from a compatible sibling donor, but died of refractory leukaemia 5 months later. The other patient died of fungal sepsis. These are the first two patients reported to have TA associated with myelodysplasia/secondary leukaemia.