Modification of antitumor effect of vincristine by natural avermectins
Driniaev, V.A.; Mosin, V.A.; Krugliak, E.B.; Sterlina, T.C.; Novik, T.C.; Ermakova, N.V.; Kublik, L.N.; Levitman, M.K.; Shaposhnikova, V.V.; Korystov, I.N.
Antibiotiki i Khimioterapiia 49(6): 3-5
2004
ISSN/ISBN: 0235-2990 PMID: 15628793 Document Number: 580392
The effect of avermectins (aversectin C, aversectin C1 and avermectin B1) on the vincristine antitumor action with respect to murine transplantable tumors was studied. It was shown that both the natural avermectins mixtures and the individual avermectin B1 potentiated the antitumor action of vincristine on Ehrlich carcinoma, melanoma B16 and P388 lymphoid leukemia, including the vincristine resistant strain P388. Such an effect of the avermectins was observed only when they were administered after vincristine.