A novel community health worker tool outperforms WHO clinical staging for assessment of antiretroviral therapy eligibility in a resource-limited setting
Macpherson, P.; Lalloo, D.G.; Thindwa, D.; Webb, E.L.; Squire, S.B.; Chipungu, G.A.; Desmond, N.; Makombe, S.D.; Taegtmeyer, M.; Choko, A.T.; Corbett, E.L.
Journal of Acquired Immune Deficiency Syndromes 65(2): E74-E78
2014
ISSN/ISBN: 1944-7884 PMID: 23846567 DOI: 10.1097/qai.0b013e3182a20e74Document Number: 579746
The accuracy of a novel community health worker antiretroviral therapy eligibility assessment tool was examined in community members in Blantyre, Malawi. Nurses independently performed World Health Organization (WHO) staging and CD4 counts. One hundred ten (55.6%) of 198 HIV-positive participants had a CD4 count of <350 cells per cubic millimeter. The community health worker tool significantly outperformed WHO clinical staging in identifying CD4 count of <350 cells per cubic millimeter in terms of sensitivity (41% vs. 19%), positive predictive value (75% vs. 68%), negative predictive values (53% vs. 47%), and area under the receiver-operator curve (0.62 vs. 0.54; P = 0.017). Reliance on WHO staging is likely to result in missed and delayed antiretroviral therapy initiation.