Medium sized rings from alprenolol and oxprenolol
Görlitzer, K.; Lorenz, A.
Die Pharmazie 59(10): 763-769
2004
ISSN/ISBN: 0031-7144 PMID: 15544054 Document Number: 577483
The N-allyl derivatives 2 formed from the beta-blockers 1, were acetylated to give the esters 5. The 1,5-benzoxazacycloundecine 6a and the 1,10,5-benzodioxazacyclododecine 7a were isolated by ring closing metathesis (RCM) of 5a and 5b, respectively, using Grubbs catalyst in the presence of titanium tetraisopropanolate. Alkaline hydrolysis yielded the alcohols 6b and 7b.
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