Acute regulation of the facilitative glucose transporter GLUT1 in a hematopoietic cell line
Hakim, G.; Fiorentini, D.; Maraldi, T.; Landi, L.
Italian Journal of Biochemistry 53(4): 135-140
2004
ISSN/ISBN: 0021-2938 PMID: 15997905 Document Number: 575583
This brief review is focused on the short-term regulation of the facilitative glucose transporter GLUT1 in megakaryocytic cells M07e. The effects of cytokines such as TPO, GM-CSF and SCF and of a low dose of H202 on the transport activity and its kinetic parameters are compared. The possible mechanisms and the signalling pathways involved in the glucose uptake activation are discussed. A role for the cellular redox status in glucose uptake control, possibly related to the status of redox-sensitive enzymes such as tyrosine phosphatases, is suggested.