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Photodynamic approaches to elimination and prevention of atherosclerotic changes in the vessels

Vozovikov, I.N.; Andreeva, E.R.; Kuz'min, S.G.

Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 90(5): 569-576

2004

ISSN/ISBN: 0869-8139
PMID: 15341082
Document Number: 575077
Photodynamic therapy (PDT) is a method based on a selective accumulation of a photo-sensitive dye in the target cells with their subsequent destruction with the aid of a low-intensity laser radiation of a certain wavelength. It is widely used today in clinical practice, mostly in oncology. This review elucidates possibilities of using the PDT in prophylactics and treatment of cardiovascular pathological conditions, atherosclerosis in particular. Data are cited indicating a successful application of the PDT for preventing the intima hyperplasia following and angioplasty. A possibility of using the PDT for treatment and prophylactics of atherosclerotic alterations in the vessels with due consideration of specifics of formation and cullular composition of the atherosclerotic lesions.

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