The relationship between lymphangiogenesis and cervical lymph node micrometastasis in oral squamous cell carcinoma
Xie, Z.-j.; Yang, X.-f.; Fan, J.; Zhang, Y.-k.; Wu, Q.-l.; Gu, Z.-y.
Zhonghua Kou Qiang Yi Xue Za Zhi 39(3): 221-223
2004
ISSN/ISBN: 1002-0098 PMID: 15196391 Document Number: 574659
To probe the relationship between lymphangiogenesis and cervical lymph node micrometastasis in oral squamous cell carcinoma. The microlymphatic vessel density was detected with enzyme histo-chemical method in 47 cases of oral squamous cell carcinoma and 10 cases of normal oral mucosa; 355 lymphnodes were detected with immunohistochemically using monoantibody AE3. The mean MLVD was 14.04 +/- 6.92 in tumor group, or 5.48 +/- 2.62 in normal group. The difference was (P < 0.001). The percentage of tumor with expression CK was 48.9%. The mean MLVD was 16.94 +/- 5.43 in CK positive group, or 11.26 +/- 5.00 in CK negative group, There was difference significant (P < 0.001). Lymphangiogenesis plays a key role in cervical lymph node micrometastasis of oral squamous cell carcinoma.