Locomotor reactions and excitability of neurons during the blockade of dopamine by haloperidol in vertebrate and invertebrate animals
Zvezdochkina, N.V.; Muranova, L.N.; Andrianov, V.V.; Arkhipova, S.S.; Gaĭnutdinov, K.L.; Golubev, A.I.; Pleshchinskiĭ, I.N.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 90(11): 1381-1392
2004
ISSN/ISBN: 0869-8139 PMID: 15646206 Document Number: 574610
Two groups of rats with different level of motor activities: high- and low-active animals, were distinguished. The blockade of dopamine receptors by haloperidol led to depression of locomotor activity in both groups of rats; in grape snails, haloperidol caused a decrease of the velocity of locomotor responses. In was found that within 5 minutes of intravenous injection of haloperidol the excitability of spinal centers of rats decreased; but in 30 minutes in started restoring. Chronic application of the preparation depressed the effect of posttetanic potentiation of H-response in gastrocnemius muscle of spinal rats. In command neurons of grape snail, chronic injections of haloperidol causes a significant hyperpolarization shift of membrane potential and an increase of threshold of the generation of action potential. It was shown that the selective pharmacological inhibition of dopaminergic system of the brain led to a decrease of excitability in some determined neurons of the snail and spinal motor centers of rats, as well as inhibited the locomotor responses both in vertebrate and in invertebrate animals.