Total lymphocyte count is a reliable surrogate marker for CD4 cell counts after the first year of antiretroviral therapy: data from an Indonesian cohort study
De Jong, M.A.; Wisaksana, R.; Meijerink, H.; Indrati, A.; van de Ven, A.J.A.M.; Alisjahbana, B.; van Crevel, R.
Tropical Medicine and International Health Tm and Ih 17(5): 581-583
2012
ISSN/ISBN: 1365-3156 PMID: 22364582 DOI: 10.1111/j.1365-3156.2012.02961.xDocument Number: 573959
Many studies have evaluated the total lymphocyte count (TLC) as a cheap surrogate marker for CD4 cells in HIV-infected patients not receiving antiretroviral therapy (ART). We assessed whether TLC can replace CD4 cell counts in evaluating the immunological response to ART. In a cohort of patients in Indonesia TLC, if measured after at least 1-year ART, correctly identified patients with <200 CD4 cells, and reliably excluded immunological failure, obviating the need for CD4 cell measurement in 43% of patients.
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