An attempt for standardization of serum CA19-9 levels, in order to dissolve the gap between three different methods
Hayashi, K.; Hoshino, T.; Yanai, M.; Tsuchiya, T.; Kumasaka, K.; Kawano, K.
Rinsho Byori. Japanese Journal of Clinical Pathology 52(6): 500-505
2004
ISSN/ISBN: 0047-1860 PMID: 15283162 Document Number: 572757
It is well known that serious method-related differences exist in results of serum CA19-9, and the necessity of standardization has been pointed out. In this study, differences of serum tumor marker CA19-9 levels obtained by various immunoassay kits (CLEIA, FEIA, LPIA and RIA) were evaluated in sixty-seven clinical samples and five calibrators and the possibility to improve the inter-methodological differences were observed not only for clinical samples but also for calibrators. We supposed an assumed standard material using by a calibrator. We calculated the serum levels of CA19-9 when using the assumed standard material for three different measurement methods. We approximate the CA19-9 values using by this method. It is suggested that the obtained CA19-9 values could be approximated by recalculation with the assumed standard material would be able to correct between-method and between-laboratory discrepancies in particular systematic errors.