New fields of research in pharmacological antiarrhythmic therapy
Hatem, S.
Archives des Maladies du Coeur et des Vaisseaux 97(11): 1054-1057
2004
ISSN/ISBN: 0003-9683 PMID: 15609906 Document Number: 572032
Large scale clinical trials, the growth of ablative techniques and introduction of implantable defibrillators have marginalised pharmacological treatment of cardiac arrhythmias. However, the development of molecules targeting ionic currents or channels with specific tissular expressions could reverse this situation. In addition, advances in genetics in cellular therapy could open new perspectives for antiarrhythmic treatments. Finally, our knowledge of the molecular and cellular bases of arrhythmias and the role played by different neuro-hormonal systems have identified new therapeutic targets which often allow intervention before the occurrence of an arrhythmia.