A new actin-binding area of the myosin light chains' high-molecular kinase
Vilitkevich, E.L.; Kudriashev, D.S.; Stepanova, O.V.; Shirinskiĭ, V.P.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 90(5): 577-585
2004
ISSN/ISBN: 0869-8139 PMID: 15341083 Document Number: 568594
High-molecular weight isoform of myosin light chain kinase (MLCK-210) contains a unique N-terminal domain not present in a low-molecular weight isoform, MLCK-108. Functional features of this domain are poorly studied. We provide evidence that N-terminal area of the unique MLCK-210 domain incorporates previously unrecognized actin-binding region that could be involved in the interaction of MLCK-210 with the actin cytoskeleton.