Effect of lycopene on blood lipoproteids in women with type 2 diabetes mellitus in postmenopause
Olfer'ev, A.M.; Il'ina, M.V.; Berzak, N.V.; Stetsenko, A.V.; Olfer'ev, M.A.; Chudakova, I.A.; Kapitanov, A.B.; Shamarin, V.M.
Voprosy Pitaniia 73(1): 19-23
2004
ISSN/ISBN: 0042-8833 PMID: 15049152 Document Number: 568313
Blind randomized placebo-control research included 39 women. The following criteria were: menopause period for more then 1 year long; diabetes mellitus; arterial hypertension; hypercholesterolemia. The patients were divided into two groups. Women from the first group (N = 24) were given 30 mg lycopene (composed with "Tomatol") per day during 24 weeks. The second group (N = 15) were given placebo. It was showed that during 12-week "Tomatol" intake we state that lycopene concentration in serum increased twice (337.0 +/- 133.0 nM), total cholesterol (CH) and CH LDL decreased by 12% and 16% respectively. The lipoproteins spectrum normalization correlated to serum antioxidative activity (r = 0.30, p < 0.05), and malonic dialdehyde concentration decrease by 44.8% correlated to lycopene increase (r = -0.51, p < 0.05). Our results give us a possibility to use "Tomatol" as an additional medicine for the prevention of atherosclerosis.