Large cell neuroendocrine carcinoma of the uterine corpus metastatic to brain and lung: case report and review of the literature
Erhan, Y.; Dikmen, Y.; Yucebilgin, M.S.; Zekioglu, O.; Mgoyi, L.; Terek, M.C.
European Journal of Gynaecological Oncology 25(1): 109-112
2004
ISSN/ISBN: 0392-2936 PMID: 15053077 Document Number: 568303
Neuroendocrine carcinoma of the uterine corpus is a rare aggressive tumor with a similar unfavorable outcome to that of the cervix. The large cell type is considerably rarer than the small cell neuroendocrine carcinoma of the uterine corpus. We report a case of a 52-year-old woman who presented with a large cell neuroendocrine tumor of the uterine corpus with very aggressive clinical behavior, cerebral and pulmonary metastases six and four months after initial diagnosis and adjuvant radiotherapy, respectively. Despite successful surgical extirpation of the cerebral metastatic lesion she did not respond to chemotherapy and died four months after disease recurrence.